Gemigliptin is an orally bioavailable inhibitor of the serine protease dipeptidyl peptidase 4 (DPP-4), with hypoglycemic and potential renoprotective activities. Upon administration, gemigliptin binds to DPP-4 and inhibits the breakdown of the incretin hormones, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP).). This prolongs incretin activity, increases.
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Effects of Gemigliptin Versus Sitagliptin or Glimepiride With Metformin on Glucose Variability(MAGE, Glucose SD) Patients With Type 2 DM(STABLE Study) - Full Text View.Read More
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Gemigliptin a new DPP-4 inhibitor is marketed in Korea since 2012. The study compared the efficacy and safety of gemigliptin (G) 50mg QD vs. vildagliptin (V) 50mg BID as add-on therapy to metformin in type 2 diabetes mellitus Russian patients (pts) uncontrolled on metformin. This was a multicenter comparative randomized (1:1) open-label 24- week non-inferiority trial (predefined equivalence.Read More
Gemigliptin (), previously identified as LC15-0444, is an oral anti-hyperglycemic agent (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. It is well known that (citation needed) glucose lowering effects of DPP-4 inhibitors are mainly mediated by GLP-1 and gastric inhibitory polypeptide (GIP) incretin hormones which are inactivated by DPP-4.Read More
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